Unlocking the Potential of Fisetin: A Dive into Senolytics and Beyond
In the realm of health and longevity, discoveries often emerge from the unlikeliest sources. Fisetin, a bioactive flavonoid found abundantly in nature, particularly in fruits and vegetables, has recently stepped into the spotlight for its remarkable properties. Remarkably, just 100 mg of pure fisetin equals the consumption of approximately 60 strawberries! This compound boasts an impressive array of biological activities, including anti-inflammatory, antioxidant, and neurotrophic1 effects. However, its most notable claim to fame lies in its role as a potent senolytic agent, capable of eliminating senescent cells—oftentimes referred to as "Zombie cells."
Cellular Senescence
Cellular senescence is a natural process activated in stressed cells to prevent their proliferation due to damage.2 Senescent cells, sometimes dubbed "Zombie cells," cease to divide and can accumulate in tissues over time, contributing to aging and age-related diseases by secreting inflammatory molecules. Senolytics, on the other hand, are compounds designed to selectively induce the death or clearance of these dysfunctional cells, potentially delaying aging and improving healthspan.
Combatting Senescent Cells
Combatting senescent cells involves a multifaceted approach, including lifestyle changes, fasting, and the use of senolytic compounds like fisetin. Incorporating regular exercise, a balanced diet rich in antioxidants, and adequate sleep can help reduce cellular stress and the accumulation of senescent cells.
Health Benefits
Fisetin offers several health benefits, including its senolytic, anti-inflammatory, antioxidant, and neuroprotective properties. While most of these benefits are supported by preclinical data, promising results from human clinical trials suggest fisetin's potential as a complementary therapy, particularly in reducing inflammation.3
Fisetin, with a recommended dosage of 100 mg per day, has been deemed safe, especially considering its natural abundance in various fruits and vegetables. At Arcwell, we ensure the highest quality and purity of fisetin, isolated from Rhus succedanea, a plant renowned for its fisetin content.
Arcwell Fisetin
Arcwell Fisetin stands out as the first Health Canada approved fisetin available in the Canadian market. Our commitment to quality is unwavering, evidenced by rigorous testing protocols, including in-house HPLC and NMR spectrometry, ensuring both efficacy and safety in every batch. With Arcwell Fisetin, you can unlock the full potential of this remarkable compound, paving the way for a healthier, more vibrant future.
Join us at Arcwell as we embark on a journey towards longevity and vitality, powered by the remarkable properties of fisetin. Together, let's unlock the secrets of cellular rejuvenation and rewrite the story of aging.
1 Biomedicines 2023, 11(11), 2878; https://doi.org/10.3390/biomedicines11112878
2 M.J. Yousefzadeh et al. EBioMedicine, 36, 18–28. https://doi.org/10.1016/j.ebiom.2018.09.015
3 Food & function, 9(4), 2025–2031. https://doi.org/10.1039/c7fo01898c
