Understanding Cellular Senescence and Senescent (Zombie) Cells: A Deep Dive

What is Cellular Senescence?

Cellular senescence is a complex biological process where cells permanently cease to divide. This phenomenon, while a natural part of aging, results in the accumulation of senescent cells that can disrupt normal cellular functions. Senescent cells are often referred to as 'zombie' cells because they remain metabolically active but can no longer contribute to tissue regeneration.

The Impact of Senescent Cells

As these senescent cells accumulate, they secrete inflammatory cytokines, growth factors, and proteases collectively known as the senescence-associated secretory phenotype (SASP). The SASP can damage neighboring cells, promote chronic inflammation, and drive the progression of age-related diseases such as arthritis, cardiovascular diseases, and neurodegenerative disorders.

Immune System and Aging

The immune system plays a crucial role in identifying and clearing senescent cells. However, with aging, the efficiency of the immune system declines, leading to an increased burden of senescent cells and contributing to the deterioration of tissue function and the onset of age-related diseases.

The Promise of Fisetin

Recent studies have highlighted Fisetin, a natural flavonoid found in many fruits and vegetables, as a potential senolytic agent. Senolytics are compounds that selectively induce death of senescent cells. Research indicates that Fisetin can reduce the burden of senescent cells, decrease the SASP, and improve tissue function and lifespan in animal models.

Arcwell's Senolytic Fisetin (Effective Formula)

At Arcwell, we believe in the power of simplicity and effectiveness. That's why we've chosen to use a single active ingredient, Fisetin, in our dietary supplement to promote cellular health. Fisetin works by reducing senescent cells, which supports overall health and longevity.

We are proud to introduce Arcwell Fisetin as the first Health Canada-approved Fisetin in the Canadian market. Our commitment to quality is unwavering. We ensure rigorous testing through in-house HPLC and NMR spectrometry, along with third-party certified labs, to guarantee both efficacy and safety.

Arcwell Fisetin, recommended at a dosage of 100 mg per day, is derived from Rhus succedanea, a plant known for its high Fisetin content. We source our Fisetin from Canadian Novusetin®, ensuring the highest quality and purity in every batch. With Arcwell Fisetin, you can trust that you are getting a supplement that supports your journey to better health and longevity.

Scientific Support

• "Cellular Senescence: Linking Cancer and Aging" - Campisi, J. (2005). This paper discusses the dual role of senescence in cancer prevention and aging.
• "Senescence, Cellular" - Childs, B.G., Durik, M., Baker, D.J., & van Deursen, J.M. (2015). Reviews the impact of senescent cells on aging and disease.
• "Immune Surveillance of Senescent Cells" - Sagiv, A., & Krizhanovsky, V. (2013). Highlights the role of the immune system in clearing senescent cells.
• "Fisetin is a senotherapeutic that extends health and lifespan" - Yousefzadeh, M.J., et al. (2018). Demonstrates the senolytic effects of Fisetin in preclinical models.
• "Natural product Fisetin alleviates various age-associated disorders" - Zhu, Y., et al. (2017). Provides evidence of Fisetin's benefits in reducing senescent cell burden.

Conclusion

As the scientific community continues to explore the mechanisms and impacts of cellular senescence, compounds like Fisetin hold great promise. Arcwell’s commitment to incorporating these scientific advancements into their products underscores their dedication to promoting health and wellness through innovative, nature-derived solutions.

Explore the science behind cellular health with Arcwell, and take a step towards a healthier tomorrow.

For more details, watch the educational video accompanying this article.